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Disclosures: Rodolphe SOBESKY: Orphalan: Consultant, AbbVie: Consultant, Christophe Desterke: Nothing to Disclose, Aurelia Poujois: Nothing to Disclose, Eleonora De Martin: Nothing to Disclose, Ilias Kounis: Nothing to Disclose, Cyrille Feray: Nothing to Disclose, Jean-Charles Duclos-Vallee: Nothing to Disclose, Audrey Coilly: Nothing to Disclose 2533 CLINICAL AND LABORATORY PROFILE OF ADULT PATIENTS WITH IDIOPATHIC CHOLESTATIC LIVER DISEASE ACCORDINGTO THE PRESENCE OF MDR3 MUTATIONS Paulo Bittencourt 1 Vivian Rotman 2 Lvia Geovana Celestino 3 Antonio Ricardo Andrade 4 Liana Codes 5 Raimundo Gama 3 Raymundo Parana 6 Larissa Athayde Costa 7 Maria Ferraz 3 Gilda Porta 8 , 1 Bahiana School of Medicine and Public Health, 2 Federal University of Rio de Janeiro, 3 Federal University of Sao Paulo, 4 Federal University of Bahia, 5 Portuguese Hospital of Salvador, Bahia, 6 Instituto D'Or de Pesquisa e Ensino, 7 Mendelics Analise Genomica, 8 University of Sao Paulo School of Medicine Background: In adult patients, MDR3 deficiency has been recognized after genetic testing in up to a third of the subjects with cholestatic liver disease (CLD) of unknown cause

While ozone therapy has the potential to enhance erythrocyte characteristics, correct hypoxia in diseases, and increase ATP levels through glycolysis activation, precise application is essential to avoid toxicity concerns [30]

Gently pat into skin until fully absorbed